Molekulare und zelluläre Mechanismen der Herzinsuffizienz

• Mahmoud Abdellatif, MD, PhD (Assistant Professor)
• Alina Stockner, PhD student
  Her project focuses on the regulation of lipid alterations in heart failure with preserved ejection fraction.
• Verma Daksh, PhD student
  His project focuses on heart-specific effects of exercise and NAD⁺ metabolism in the setting of cardiometabolic risk.
• Viktoria Trummer-Herbst, biomedical assistant

• Nika Barbara Pravica, MD (BioTechMed lab rotation)
• Jan Schafmeister, MD
• Hendrik Jöst, MD
• Simon Kraler, MD
• Jan Esser, MD
• Alina Humnig, MSc
• Julia Voglhuber, MSC (BioTechMed lab rotation)
• Felix Renneberg, MD
• Martin Wernhart, MD
• Marinko Matovina, MD
• Clemens Reiter, MD
• Corinna Simonini, MD
• Isabella Windhager, MD
• Georg Arnstein, MD
• Eva Thon-Gutschi, MSc

• Frank Madeo (University of Graz)
• Tobias Eisenberg (University of Graz)
• Renate Schreiber (University of Graz)
• Rolf Breinbauer (Technical University of Graz)
• Kathrin Thedieck (University of Innsbruck)
• Andreas Koeberle (University of Innsbruck)
• Stefan Kiechl (Medical University of Innsbruck)
• Manuel Mayr (Medical University Wien/King’s College London)

• Guido Kroemer (University of Sorbonne, France)
• Christian Mühlfeld (Medical School Hannover, Germany)
• Junichi Sadoshima (New Jersey Medical School, USA)
• Abhinav Diwan (Washington University, USA)
• Jorge Alegre-Cebollada (CNIC, Spain)
• Wolfgang Linke (University of Münster, Germany)
• Julie McMullen (Baker Heart Institute, Australia)

1. Abdellatif M, […], Kroemer G, and Sedej S (2022). Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity. Circulation. 145(25): 1853-1866. doi:10.1161/CIRCULATIONAHA.122.059863.

2. Abdellatif M, […], Kroemer G, and Sedej S (2021). Nicotinamide for the treatment of heart failure with preserved ejection fraction. Science Translational Medicine. 13 (580), eabd7064. doi:10.1126/scitranslmed.abd7064.

3. Eisenberg T, Abdellatif M, […], Kroemer G, Sedej S, and Madeo F (2016). Cardioprotection and life span extension by the natural polyamine spermidine. Nature Medicine. 22(12): 1428–1438. doi:10.1038/nm.4222. #equally contributed and corresponding authors.

4. Abdellatif M, Sedej S, and Kroemer G (2021). NAD⁺ metabolism in cardiac health, aging and disease. Circulation. 144(22):1795-1817. doi:10.1161/CIRCULATIONAHA.121.056589.

5. Ljubojevic-Holzer S and Kraler S, […], Sedej S (2021). Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca²⁺ cycling. Cardiovascular Research. cvab112. doi:10.1093/cvr/cvab112.

6. Abdellatif M and Sedej S (2022).Metabolic therapy for managing heart failure with preserved ejection fraction. Journal of Molecular and Cellular Cardiology. 168:68-69. doi: 10.1016/j.yjmcc.2022.04.009.

7. Abdellatif M, Sedej S, Carmona-Gutierrez D, Madeo F, and Kroemer G (2018). Autophagy in Cardiovascular Aging. Circulation Research. 123(7): 803–824. doi:10.1161/CIRCRESAHA.118.312208.

8. Abdellatif M, […], and Sedej S. (2020) Autophagy in cardiovascular health and disease. Progress in Molecular Biology and Translational Science. 172:87-106. doi:10.1016/bs.pmbts.2020.04.022.

9. Sedej S, […], and Pieske B. (2014). Subclinical abnormalities in sarcoplasmic reticulum Ca²⁺ release promote eccentric myocardial remodeling and pump failure death in response to pressure overload. Journal of the American College of Cardiology. 63(15):1569-79. doi:10.1016/j.jacc.2013.11.010.

10. Sedej S, […], and Pieske B. (2010). Na⁺-dependent SR Ca²⁺ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation. Cardiovascular Research. 87(1):50-9. doi: 10.1093/cvr/cvq007

Full publications list (Pubmed): https://pubmed.ncbi.nlm.nih.gov/?term=sedej+s&sort=date